Metformin attenuates pressure overload-induced cardiac hypertrophy via AMPK activation

AIM: To identify the role of metformin in cardiac hypertrophy and investigate the possible mechanism underlying this effect. METHODS: Wild type and AMPKα2 knockout (AMPKα2(−/−)) littermates were subjected to left ventricular pressure overload caused by transverse aortic constriction. After administr...

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Bibliografiske detaljer
Main Authors: Fu, Yong-nan, Xiao, Han, Ma, Xiao-wei, Jiang, Sheng-yang, Xu, Ming, Zhang, You-yi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003117/
https://ncbi.nlm.nih.gov/pubmed/21552292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2010.229
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