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Metformin attenuates pressure overload-induced cardiac hypertrophy via AMPK activation
AIM: To identify the role of metformin in cardiac hypertrophy and investigate the possible mechanism underlying this effect. METHODS: Wild type and AMPKα2 knockout (AMPKα2(−/−)) littermates were subjected to left ventricular pressure overload caused by transverse aortic constriction. After administr...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4003117/ https://ncbi.nlm.nih.gov/pubmed/21552292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2010.229 |
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