MET-GRB2 Signaling-Associated Complexes Correlate with Oncogenic MET Signaling and Sensitivity to MET Kinase Inhibitors

PURPOSE: Targeting MET in cancer is hampered by lack of diagnostics that accurately reflect high MET signaling and dependence. We hypothesized that assays reflecting MET signaling associated protein complexes could redefine tumors dependent on MET and could add additional precision beyond genomic as...

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Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Main Authors: Smith, Matthew A., Licata, Thomas, Lakhani, Aliya, Garcia, Marileila Varella, Schildhaus, Hans-Ulrich, Vuaroqueaux, Vincent, Halmos, Balazs, Borczuk, Alain C., Chen, Y. Ann, Creelan, Benjamin C., Boyle, Theresa A., Haura, Eric B.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833309/
https://ncbi.nlm.nih.gov/pubmed/28855353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-3006
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