PHLDA2 is a key oncogene-induced negative feedback inhibitor of EGFR/ErbB2 signaling via interference with AKT signaling

Pleckstrin homology-like domain family A member 2 (PHLDA2) is located within the tumor suppressor region of 11p15, and its expression is suppressed in several malignant tumor types. We recently identified PHLDA2 as a robustly induced, novel downstream target of oncogenic EGFR/ErbB2 signaling. In an...

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Publicat a:Oncotarget
Autors principals: Wang, Xiaoqi, Li, Guangyuan, Koul, Sanjay, Ohki, Rieko, Maurer, Matthew, Borczuk, Alain, Halmos, Balazs
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5982771/
https://ncbi.nlm.nih.gov/pubmed/29861842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.3674
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