MET-GRB2 Signaling-Associated Complexes Correlate with Oncogenic MET Signaling and Sensitivity to MET Kinase Inhibitors

PURPOSE: Targeting MET in cancer is hampered by lack of diagnostics that accurately reflect high MET signaling and dependence. We hypothesized that assays reflecting MET signaling associated protein complexes could redefine tumors dependent on MET and could add additional precision beyond genomic as...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Smith, Matthew A., Licata, Thomas, Lakhani, Aliya, Garcia, Marileila Varella, Schildhaus, Hans-Ulrich, Vuaroqueaux, Vincent, Halmos, Balazs, Borczuk, Alain C., Chen, Y. Ann, Creelan, Benjamin C., Boyle, Theresa A., Haura, Eric B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833309/
https://ncbi.nlm.nih.gov/pubmed/28855353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-3006
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