Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors

RUNX1 is crucial for the regulation of megakaryocyte specification, maturation, and thrombopoiesis. Runx1 possesses 2 promoters: the distal P1 and proximal P2 promoters. The major protein isoforms generated by P1 and P2 are RUNX1C and RUNX1B, respectively, which differ solely in their N-terminal ami...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Draper, Julia E., Sroczynska, Patrycja, Leong, Hui Sun, Fadlullah, Muhammad Z. H., Miller, Crispin, Kouskoff, Valerie, Lacaud, Georges
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2017
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833261/
https://ncbi.nlm.nih.gov/pubmed/28490570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-06-723635
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