Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes

We reported that amyloid β peptide (Aβ(42)) activated neutral SMase 2 (nSMase2), thereby increasing the concentration of the sphingolipid ceramide in astrocytes. Here, we show that Aβ(42) induced mitochondrial fragmentation in wild-type astrocytes, but not in nSMase2-deficient cells or astrocytes tr...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:J Lipid Res
Main Authors: Kong, Ji-Na, Zhu, Zhihui, Itokazu, Yutaka, Wang, Guanghu, Dinkins, Michael B., Zhong, Liansheng, Lin, Hsuan-Pei, Elsherbini, Ahmed, Leanhart, Silvia, Jiang, Xue, Qin, Haiyan, Zhi, Wenbo, Spassieva, Stefka D., Bieberich, Erhard
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Biochemistry and Molecular Biology 2018
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832933/
https://ncbi.nlm.nih.gov/pubmed/29321137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M081877
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla