Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice

Sphingolipids are key signaling lipids in cancer. Genome-wide studies have identified neutral SMase-2 (nSMase2), an enzyme generating ceramide from SM, as a potential repressor for hepatocellular carcinoma. However, little is known about the sphingolipids regulated by nSMase2 and their roles in live...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Zhong, Liansheng, Kong, Ji Na, Dinkins, Michael B., Leanhart, Silvia, Zhu, Zhihui, Spassieva, Stefka D., Qin, Haiyan, Lin, Hsuan-Pei, Elsherbini, Ahmed, Wang, Rebecca, Jiang, Xue, Nikolova-Karakashian, Mariana, Wang, Guanghu, Bieberich, Erhard
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928441/
https://ncbi.nlm.nih.gov/pubmed/29567647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M080879
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