Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes

We reported that amyloid β peptide (Aβ(42)) activated neutral SMase 2 (nSMase2), thereby increasing the concentration of the sphingolipid ceramide in astrocytes. Here, we show that Aβ(42) induced mitochondrial fragmentation in wild-type astrocytes, but not in nSMase2-deficient cells or astrocytes tr...

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Vydáno v:J Lipid Res
Hlavní autoři: Kong, Ji-Na, Zhu, Zhihui, Itokazu, Yutaka, Wang, Guanghu, Dinkins, Michael B., Zhong, Liansheng, Lin, Hsuan-Pei, Elsherbini, Ahmed, Leanhart, Silvia, Jiang, Xue, Qin, Haiyan, Zhi, Wenbo, Spassieva, Stefka D., Bieberich, Erhard
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832933/
https://ncbi.nlm.nih.gov/pubmed/29321137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M081877
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