An intrinsic lipid-binding interface controls sphingosine kinase 1 function

Sphingosine kinase 1 (SK1) is required for production of sphingosine-1-phosphate (S1P) and thereby regulates many cellular processes, including cellular growth, immune cell trafficking, and inflammation. To produce S1P, SK1 must access sphingosine directly from membranes. However, the molecular mech...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Pulkoski-Gross, Michael J., Jenkins, Meredith L., Truman, Jean-Philip, Salama, Mohamed F., Clarke, Christopher J., Burke, John E., Hannun, Yusuf A., Obeid, Lina M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832922/
https://ncbi.nlm.nih.gov/pubmed/29326159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M081307
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