A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma

Sphingosine kinase 1 (SK1), the enzyme responsible for sphingosine 1-phosphate (S1P) production, is overexpressed in many human solid tumors. However, its role in clear cell renal cell carcinoma (ccRCC) has not been described previously. ccRCC cases are usually associated with mutations in von Hippe...

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Опубликовано в: :FASEB J
Главные авторы: Salama, Mohamed F., Carroll, Brittany, Adada, Mohamad, Pulkoski-Gross, Michael, Hannun, Yusuf A., Obeid, Lina M.
Формат: Artigo
Язык:Inglês
Опубликовано: Federation of American Societies for Experimental Biology 2015
Предметы:
Research Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478804/
https://ncbi.nlm.nih.gov/pubmed/25805832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-270413
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