Intracellular sphingosine kinase 2–derived sphingosine-1-phosphate mediates epidermal growth factor–induced ezrin-radixin-moesin phosphorylation and cancer cell invasion

The bioactive sphingolipid sphingosine-1-phosphate (S1P) mediates cellular proliferation, mitogenesis, inflammation, and angiogenesis. These biologies are mediated through S1P binding to specific GPCRs [sphingosine-1-phosphate receptor (S1PR)1–5] and some other less well-characterized intracellular...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Adada, Mohamad M., Canals, Daniel, Jeong, Nara, Kelkar, Ashwin D., Hernandez-Corbacho, Maria, Pulkoski-Gross, Michael J., Donaldson, Jane C., Hannun, Yusuf A., Obeid, Lina M.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2015
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608912/
https://ncbi.nlm.nih.gov/pubmed/26209696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-274340
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