A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma

Sphingosine kinase 1 (SK1), the enzyme responsible for sphingosine 1-phosphate (S1P) production, is overexpressed in many human solid tumors. However, its role in clear cell renal cell carcinoma (ccRCC) has not been described previously. ccRCC cases are usually associated with mutations in von Hippe...

Full description

Saved in:
Bibliographic Details
Published in:FASEB J
Main Authors: Salama, Mohamed F., Carroll, Brittany, Adada, Mohamad, Pulkoski-Gross, Michael, Hannun, Yusuf A., Obeid, Lina M.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2015
Subjects:
Research Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478804/
https://ncbi.nlm.nih.gov/pubmed/25805832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-270413
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items