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Spontaneous CRISPR loci generation in vivo by non-canonical spacer integration
The adaptation phase of CRISPR-Cas immunity depends on the precise integration of short segments of foreign DNA (spacers) into a specific genomic location within the CRISPR locus by the Cas1-Cas2 integration complex. Although off-target spacer integration outside of canonical CRISPR arrays has been...
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| Publicado no: | Nat Microbiol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5832444/ https://ncbi.nlm.nih.gov/pubmed/29379209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-017-0097-z |
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