ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2

Mechanisms regulating mammalian meiotic progression are poorly understood. Here we identify mouse YTHDC2 as a critical component. A screen yielded a sterile mutant, ‘ketu’, caused by a Ythdc2 missense mutation. Mutant germ cells enter meiosis but proceed prematurely to aberrant metaphase and apoptos...

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Publicado en:eLife
Autores principales: Jain, Devanshi, Puno, M Rhyan, Meydan, Cem, Lailler, Nathalie, Mason, Christopher E, Lima, Christopher D, Anderson, Kathryn V, Keeney, Scott
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832417/
https://ncbi.nlm.nih.gov/pubmed/29360036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30919
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