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ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2
Mechanisms regulating mammalian meiotic progression are poorly understood. Here we identify mouse YTHDC2 as a critical component. A screen yielded a sterile mutant, ‘ketu’, caused by a Ythdc2 missense mutation. Mutant germ cells enter meiosis but proceed prematurely to aberrant metaphase and apoptos...
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| 出版年: | eLife |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2018
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5832417/ https://ncbi.nlm.nih.gov/pubmed/29360036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30919 |
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