Developing Spindlin1 Small Molecule Inhibitors Using Protein Microarrays

The discovery of inhibitors of methyl- and acetyl-binding domains has provided evidence for the “druggability” of epigenetic effector molecules. The small molecule probe UNC1215 prevents methyl-dependent protein-protein interactions by engaging the aromatic cage of MBT domains, and with lower affini...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Bae, Narkhyun, Viviano, Monica, Su, Xiaonan, Lv, Jie, Cheng, Donghang, Sagum, Cari, Castellano, Sabrina, Bai, Xue, Johnson, Claire, Khalil, Mahmoud Ibrahim, Shen, Jianjun, Chen, Kaifu, Li, Haitao, Sbardella, Gianluca, Bedford, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831360/
https://ncbi.nlm.nih.gov/pubmed/28504676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2377
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados