Novel 3,5-Bis(bromohydroxybenzylidene)piperidin-4-ones as Coactivator-associated Arginine Methyltransferase 1 Inhibitors: Enzyme Selectivity and Cellular Activity

Coactivator-associated arginine methyltransferase 1 (CARM1) represents a valuable target for hormone-dependent tumors such as prostate and breast cancers. Here we report the enzyme and cellular characterization of the 1-benzyl-3,5-bis(3-bromo-4-hydroxybenzylidene) piperidin-4-one (7g) and its analog...

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Detalhes bibliográficos
Main Authors: Cheng, Donghang, Valente, Sergio, Castellano, Sabrina, Sbardella, Gianluca, Di Santo, Roberto, Costi, Roberta, Bedford, Mark T., Mai, Antonello
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487391/
https://ncbi.nlm.nih.gov/pubmed/21612300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200453n
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