Assessment of genotoxicity associated with hydroxyurea therapy in children with sickle cell anemia

Hydroxyurea induces fetal hemoglobin, improves laboratory parameters, and ameliorates clinical complications of sickle cell anemia (SCA), but its long-term efficacy and safety in this patient population remain incompletely defined. Although generally considered non-DNA reactive, an important safety...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mutat Res
Main Authors: Flanagan, Jonathan M., Howard, Thad A., Mortier, Nicole, Avlasevich, Svetlana L., Smeltzer, Matthew P., Wu, Song, Dertinger, Stephen D., Ware, Russell E.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831106/
https://ncbi.nlm.nih.gov/pubmed/20230905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrgentox.2010.03.001
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