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Assessment of genotoxicity associated with hydroxyurea therapy in children with sickle cell anemia

Hydroxyurea induces fetal hemoglobin, improves laboratory parameters, and ameliorates clinical complications of sickle cell anemia (SCA), but its long-term efficacy and safety in this patient population remain incompletely defined. Although generally considered non-DNA reactive, an important safety...

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Detalhes bibliográficos
Publicado no:Mutat Res
Main Authors: Flanagan, Jonathan M., Howard, Thad A., Mortier, Nicole, Avlasevich, Svetlana L., Smeltzer, Matthew P., Wu, Song, Dertinger, Stephen D., Ware, Russell E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831106/
https://ncbi.nlm.nih.gov/pubmed/20230905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrgentox.2010.03.001
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