Genotoxicity Associated with Hydroxyurea Exposure in Infants with Sickle Cell Anemia: Results from the BABY-HUG Phase III Clinical Trial

BACKGROUND: The laboratory and clinical benefits of hydroxyurea therapy for children with sickle cell anemia (SCA) are well recognized, but treatment in young patients is limited in part by concerns about long-term genotoxicity, and specifically possible carcinogenicity. PROCEDURE: The Pediatric Hyd...

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Main Authors: McGann, Patrick T., Flanagan, Jonathan M., Howard, Thad A., Dertinger, Stephen D., He, Jin, Kulharya, Anita S., Thompson, Bruce W., Ware, Russell E.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277805/
https://ncbi.nlm.nih.gov/pubmed/22012708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23365
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