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Epigenetic and molecular profiles of erythroid cells after hydroxyurea treatment in sickle cell anemia
Hydroxyurea has been shown to be efficacious for the treatment of sickle cell anemia (SCA), primarily through the induction of fetal hemoglobin (HbF). However, the exact mechanisms by which hydroxyurea can induce HbF remain incompletely defined, although direct transcriptional effects and altered ce...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society of Hematology
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3217365/ https://ncbi.nlm.nih.gov/pubmed/21921042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-368746 |
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