Epigenetic and molecular profiles of erythroid cells after hydroxyurea treatment in sickle cell anemia

Hydroxyurea has been shown to be efficacious for the treatment of sickle cell anemia (SCA), primarily through the induction of fetal hemoglobin (HbF). However, the exact mechanisms by which hydroxyurea can induce HbF remain incompletely defined, although direct transcriptional effects and altered ce...

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Detalhes bibliográficos
Main Authors: Walker, Aisha L., Steward, Shirley, Howard, Thad A., Mortier, Nicole, Smeltzer, Matthew, Wang, Yong-Dong, Ware, Russell E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217365/
https://ncbi.nlm.nih.gov/pubmed/21921042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-368746
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