Genes Associated with Pancreas Development and Function Maintain Open Chromatin in iPSCs Generated from Human Pancreatic Beta Cells

Current in vitro islet differentiation protocols suffer from heterogeneity and low efficiency. Induced pluripotent stem cells (iPSCs) derived from pancreatic beta cells (BiPSCs) preferentially differentiate toward endocrine pancreas-like cells versus those from fibroblasts (FiPSCs). We interrogated...

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Detalles Bibliográficos
Publicado en:Stem Cell Reports
Main Authors: Thurner, Matthias, Shenhav, Liraz, Wesolowska-Andersen, Agata, Bennett, Amanda J., Barrett, Amy, Gloyn, Anna L., McCarthy, Mark I., Beer, Nicola L., Efrat, Shimon
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831005/
https://ncbi.nlm.nih.gov/pubmed/29107594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.09.020
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