Genes Associated with Pancreas Development and Function Maintain Open Chromatin in iPSCs Generated from Human Pancreatic Beta Cells

Current in vitro islet differentiation protocols suffer from heterogeneity and low efficiency. Induced pluripotent stem cells (iPSCs) derived from pancreatic beta cells (BiPSCs) preferentially differentiate toward endocrine pancreas-like cells versus those from fibroblasts (FiPSCs). We interrogated...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Thurner, Matthias, Shenhav, Liraz, Wesolowska-Andersen, Agata, Bennett, Amanda J., Barrett, Amy, Gloyn, Anna L., McCarthy, Mark I., Beer, Nicola L., Efrat, Shimon
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831005/
https://ncbi.nlm.nih.gov/pubmed/29107594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.09.020
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