Genes Associated with Pancreas Development and Function Maintain Open Chromatin in iPSCs Generated from Human Pancreatic Beta Cells

Current in vitro islet differentiation protocols suffer from heterogeneity and low efficiency. Induced pluripotent stem cells (iPSCs) derived from pancreatic beta cells (BiPSCs) preferentially differentiate toward endocrine pancreas-like cells versus those from fibroblasts (FiPSCs). We interrogated...

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Bibliografiset tiedot
Julkaisussa:Stem Cell Reports
Päätekijät: Thurner, Matthias, Shenhav, Liraz, Wesolowska-Andersen, Agata, Bennett, Amanda J., Barrett, Amy, Gloyn, Anna L., McCarthy, Mark I., Beer, Nicola L., Efrat, Shimon
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2017
Aiheet:
Report
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831005/
https://ncbi.nlm.nih.gov/pubmed/29107594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.09.020
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