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The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment

The spindle assembly checkpoint plays a pivotal role in preventing aneuploidy and transformation. Many studies demonstrate impairment of this checkpoint in cancer cells. While leukemia is frequently driven by transformed hematopoietic stem and progenitor cells (HSPCs), the biology of the spindle ass...

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Bibliografiske detaljer
Udgivet i:Stem Cell Reports
Main Authors: Brown, Andreas, Pospiech, Johannes, Eiwen, Karina, Baker, Darren J., Moehrle, Bettina, Sakk, Vadim, Nattamai, Kalpana, Vogel, Mona, Grigoryan, Ani, Geiger, Hartmut
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830991/
https://ncbi.nlm.nih.gov/pubmed/29056333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.09.017
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