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Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment?: Epigenome: A Dynamic Vehicle for Transmitting and Recording Cytokine Signaling

CD4(+) T cells are critical for the elimination of an immense array of microbial pathogens. Although there are aspects of helper T-cell differentiation that can be modeled as a classic cell-fate commitment, CD4(+) T cells also maintain considerable flexibility in their transcriptional program. Here,...

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Pubblicato in:Cold Spring Harb Perspect Biol
Autori principali: Johnson, John L., Vahedi, Golnaz
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830896/
https://ncbi.nlm.nih.gov/pubmed/28432132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a028779
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