Application of Receptor Theory to the Design and Use of Fixed-Proportion Mu-Opioid Agonist and Antagonist Mixtures in Rhesus Monkeys

Receptor theory predicts that fixed-proportion mixtures of a competitive, reversible agonist (e.g., fentanyl) and antagonist (e.g., naltrexone) at a common receptor [e.g., mu-opioid receptors (MORs)] will result in antagonist proportion-dependent decreases in apparent efficacy of the agonist/antagon...

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Xehetasun bibliografikoak
Argitaratua izan da:J Pharmacol Exp Ther
Egile Nagusiak: Cornelissen, Jeremy C., Obeng, Samuel, Rice, Kenner C., Zhang, Yan, Negus, S. Stevens, Banks, Matthew L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Pharmacology and Experimental Therapeutics 2018
Gaiak:
Behavioral Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830633/
https://ncbi.nlm.nih.gov/pubmed/29330156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.246439
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