Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles

In vitro assay data have recently emerged as a potential alternative to traditional animal toxicity studies to aid in the prediction of adverse effects of chemicals on humans. Here we evaluate the data generated from a battery of quantitative high-throughput screening (qHTS) assays applied to a larg...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Huang, Ruili, Xia, Menghang, Sakamuru, Srilatha, Zhao, Jinghua, Lynch, Caitlin, Zhao, Tongan, Zhu, Hu, Austin, Christopher P., Simeonov, Anton
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830476/
https://ncbi.nlm.nih.gov/pubmed/29491351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22046-w
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