Adaptive designs in clinical trials: why use them, and how to run and report them

Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trial’s course in accordance with pre-specified rules. Trials with an adaptive design are often more efficient, informative and ethical than trials with a traditional fixed design sin...

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Detalhes bibliográficos
Publicado no:BMC Med
Principais autores: Pallmann, Philip, Bedding, Alun W., Choodari-Oskooei, Babak, Dimairo, Munyaradzi, Flight, Laura, Hampson, Lisa V., Holmes, Jane, Mander, Adrian P., Odondi, Lang’o, Sydes, Matthew R., Villar, Sofía S., Wason, James M. S., Weir, Christopher J., Wheeler, Graham M., Yap, Christina, Jaki, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Correspondence
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830330/
https://ncbi.nlm.nih.gov/pubmed/29490655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-018-1017-7
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