How to design a dose-finding study using the continual reassessment method

INTRODUCTION: The continual reassessment method (CRM) is a model-based design for phase I trials, which aims to find the maximum tolerated dose (MTD) of a new therapy. The CRM has been shown to be more accurate in targeting the MTD than traditional rule-based approaches such as the 3 + 3 design, whi...

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Dettagli Bibliografici
Pubblicato in:BMC Med Res Methodol
Autori principali: Wheeler, Graham M., Mander, Adrian P., Bedding, Alun, Brock, Kristian, Cornelius, Victoria, Grieve, Andrew P., Jaki, Thomas, Love, Sharon B., Odondi, Lang’o, Weir, Christopher J., Yap, Christina, Bond, Simon J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Technical Advance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6339349/
https://ncbi.nlm.nih.gov/pubmed/30658575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-018-0638-z
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