Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers

Histone deacetylase inhibitors (HDACIs) are known to alter gene expression by both up- and down-regulation of protein-coding genes in normal and cancer cells. However, the exact regulatory mechanisms of action remain uncharacterized. Here we investigated genome wide dose-dependent epigenetic and tra...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Sanchez, Gilson J, Richmond, Phillip A, Bunker, Eric N, Karman, Samuel S, Azofeifa, Joseph, Garnett, Aaron T, Xu, Quanbin, Wheeler, Graycen E, Toomey, Cathryn M, Zhang, Qinghong, Dowell, Robin D, Liu, Xuedong
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829637/
https://ncbi.nlm.nih.gov/pubmed/29240919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1225
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