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Protein neddylation and its alterations in human cancers for targeted therapy
Neddylation, a post-translational modification that conjugates an ubiquitin-like protein NEDD8 to substrate proteins, is an important biochemical process that regulates protein function. The best-characterized substrates of neddylation are the cullin subunits of Cullin-RING ligases (CRLs), which, as...
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| Published in: | Cell Signal |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5829022/ https://ncbi.nlm.nih.gov/pubmed/29331584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2018.01.009 |
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