Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts

Cardiac insulin resistance is a key pathogenic factor for diabetic cardiomyopathy (DCM), but the mechanism remains largely unclear. We found that diabetic hearts exhibited decreased phosphorylation of total Akt and isoform Akt2 but not Akt1 in wild-type (WT) male FVB mice, which was accompanied by a...

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Bibliografiske detaljer
Udgivet i:Diabetes
Main Authors: Gu, Junlian, Yan, Xiaoqing, Dai, Xiaozhen, Wang, Yuehui, Lin, Qian, Xiao, Jian, Zhou, Shanshan, Zhang, Jian, Wang, Kai, Zeng, Jun, Xin, Ying, Barati, Michelle T., Zhang, Chi, Bai, Yang, Li, Yan, Epstein, Paul N., Wintergerst, Kupper A., Li, Xiaokun, Tan, Yi, Cai, Lu
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2018
Fag:
Complications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828458/
https://ncbi.nlm.nih.gov/pubmed/29079702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0219
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