Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy

We have reported that sulforaphane (SFN) prevented diabetic cardiomyopathy in both type 1 and type 2 diabetes (T2DM) animal models via the upregulation of nuclear transcription factor erythroid 2–related factor 2 (Nrf2) and metallothionein (MT). In this study, we tested whether SFN protects the hear...

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Publicado en:Diabetes
Autores principales: Gu, Junlian, Cheng, Yanli, Wu, Hao, Kong, Lili, Wang, Shudong, Xu, Zheng, Zhang, Zhiguo, Tan, Yi, Keller, Bradley B., Zhou, Honglan, Wang, Yuehui, Xu, Zhonggao, Cai, Lu
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2017
Materias:
Complications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248986/
https://ncbi.nlm.nih.gov/pubmed/27903744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1274
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