Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway

AIMS: Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) by sulforaphane (SFN) protects from, and deletion of the Nrf2 gene exaggerates, diabetic cardiomyopathy. Angiotensin II (Ang II) plays a critical role in the development of diabetic cardiomyopathy. Therefore, whether SFN prevents...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Xin, Ying, Bai, Yang, Jiang, Xin, Zhou, Shanshan, Wang, Yuehui, Wintergerst, Kupper A., Cui, Taixing, Ji, Honglei, Tan, Yi, Cai, Lu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975128/
https://ncbi.nlm.nih.gov/pubmed/29353218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.12.016
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