Endothelial Overexpression of Metallothionein Prevents Diabetes-Induced Impairment in Ischemia Angiogenesis Through Preservation of HIF-1α/SDF-1/VEGF Signaling in Endothelial Progenitor Cells

Diabetes-induced oxidative stress is one of the major contributors to dysfunction of endothelial progenitor cells (EPCs) and impaired endothelial regeneration. Thus, we tested whether increasing antioxidant protein metallothionein (MT) in EPCs promotes angiogenesis in a hind limb ischemia (HLI) mode...

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Vydáno v:Diabetes
Hlavní autoři: Wang, Kai, Dai, Xiaozhen, He, Junhong, Yan, Xiaoqing, Yang, Chengkui, Fan, Xia, Sun, Shiyue, Chen, Jing, Xu, Jianxiang, Deng, Zhongbin, Fan, Jiawei, Yuan, Xiaohuan, Liu, Hairong, Carlson, Edward C., Shen, Feixia, Wintergerst, Kupper A., Conklin, Daniel J., Epstein, Paul N., Lu, Chaosheng, Tan, Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2020
Témata:
Complications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519474/
https://ncbi.nlm.nih.gov/pubmed/32404351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0829
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