Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts

Cardiac insulin resistance is a key pathogenic factor for diabetic cardiomyopathy (DCM), but the mechanism remains largely unclear. We found that diabetic hearts exhibited decreased phosphorylation of total Akt and isoform Akt2 but not Akt1 in wild-type (WT) male FVB mice, which was accompanied by a...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Gu, Junlian, Yan, Xiaoqing, Dai, Xiaozhen, Wang, Yuehui, Lin, Qian, Xiao, Jian, Zhou, Shanshan, Zhang, Jian, Wang, Kai, Zeng, Jun, Xin, Ying, Barati, Michelle T., Zhang, Chi, Bai, Yang, Li, Yan, Epstein, Paul N., Wintergerst, Kupper A., Li, Xiaokun, Tan, Yi, Cai, Lu
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828458/
https://ncbi.nlm.nih.gov/pubmed/29079702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0219
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