Endothelial Overexpression of Metallothionein Prevents Diabetes-Induced Impairment in Ischemia Angiogenesis Through Preservation of HIF-1α/SDF-1/VEGF Signaling in Endothelial Progenitor Cells

Diabetes-induced oxidative stress is one of the major contributors to dysfunction of endothelial progenitor cells (EPCs) and impaired endothelial regeneration. Thus, we tested whether increasing antioxidant protein metallothionein (MT) in EPCs promotes angiogenesis in a hind limb ischemia (HLI) mode...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Wang, Kai, Dai, Xiaozhen, He, Junhong, Yan, Xiaoqing, Yang, Chengkui, Fan, Xia, Sun, Shiyue, Chen, Jing, Xu, Jianxiang, Deng, Zhongbin, Fan, Jiawei, Yuan, Xiaohuan, Liu, Hairong, Carlson, Edward C., Shen, Feixia, Wintergerst, Kupper A., Conklin, Daniel J., Epstein, Paul N., Lu, Chaosheng, Tan, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2020
Assuntos:
Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519474/
https://ncbi.nlm.nih.gov/pubmed/32404351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0829
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