The polo-like kinase 1 inhibitor volasertib synergistically increases radiation efficacy in glioma stem cells

BACKGROUND: Despite the availability of hundreds of cancer drugs, there is insufficient data on the efficacy of these drugs on the extremely heterogeneous tumor cell populations of glioblastoma (GBM). RESULTS: The PKIS of 357 compounds was initially evaluated in 15 different GSC lines which then led...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Dong, Jianwen, Park, Soon Young, Nguyen, Nghi, Ezhilarasan, Ravesanker, Martinez-Ledesma, Emmanuel, Wu, Shaofang, Henry, Verlene, Piao, Yuji, Tiao, Ningyi, Brunell, David, Stephan, Clifford, Verhaak, Roel, Sulman, Erik, Balasubramaniyan, Veerakumar, de Groot, John F.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828226/
https://ncbi.nlm.nih.gov/pubmed/29535822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24041
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