Depletion of CLK2 sensitizes glioma stem-like cells to PI3K/mTOR and FGFR inhibitors

The Cdc2-like kinases (CLKs) regulate RNA splicing and have been shown to suppress cell growth. Knockdown of CLK2 was found to block glioma stem-like cell (GSC) growth in vivo through the AKT/FOXO3a/p27 pathway without activating mTOR and MAPK signaling, suggesting that these pathways mediate resist...

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Bibliografiske detaljer
Udgivet i:Am J Cancer Res
Main Authors: Park, Soon Young, Mittal, Sandeep, Dong, Jianwen, Jeong, Kangjin, Martinez-Ledesma, Emmanuel, Piao, Yuji, Khan, Sabbir, Henry, Verlene, Verhaak, Roel GW, Majd, Nazanin, Balasubramaniyan, Veerakumar, de Groot, John F
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2020
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7716149/
https://ncbi.nlm.nih.gov/pubmed/33294266
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