DRES-09. THERAPEUTIC TARGETING OF CLK2 AND PI3K/mTOR IN GLIOBLASTOMA STEM CELLS

Key signaling genes of the PI3K pathway are mutated in a large proportion of human glioblastoma (GBM), leading to persistent activation of the pathway. To determine the efficacy of inhibiting multiple components or the RTK/PI3K pathway, we examined GSK2126458 (PI3K/mTOR inhibitor) in a panel of glio...

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Publicado no:Neuro Oncol
Main Authors: Park, Soon Young, Dong, Jianwen, Martinez-Ledesma, Emmanuel, Piao, Yuji, Verhaak, Roel, Balasubramaniyan, Veerakumar, de Groot, John
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692817/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.267
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