Tet2-mediated Clonal Hematopoiesis Accelerates Heart Failure through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

BACKGROUND: Recent studies have shown that hematopoietic stem cells can undergo clonal expansion due to somatic mutations in leukemia-related genes, leading to an age-dependent accumulation of mutant leukocytes in the blood. This somatic mutation-related clonal hematopoiesis is common in the healthy...

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Publicat a:J Am Coll Cardiol
Autors principals: Sano, Soichi, Oshima, Kosei, Wang, Ying, MacLauchlan, Susan, Katanasaka, Yasufumi, Sano, Miho, Zuriaga, María A., Yoshiyama, Minoru, Goukassian, David, Cooper, Matthew A., Fuster, José J., Walsh, Kenneth
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828038/
https://ncbi.nlm.nih.gov/pubmed/29471939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2017.12.037
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