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Recombinant cells in the lung increase with age via de novo recombination events and clonal expansion

Homologous recombination (HR) is a critical DNA repair pathway, which is usually error-free, but can sometimes lead to cancer-promoting mutations. Despite the importance of HR as a driver of mutations, the spontaneous frequency of such mutations has proven difficult to study. In order to gain insigh...

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Detalhes bibliográficos
Publicado no:Environ Mol Mutagen
Main Authors: Kimoto, Takafumi, Kay, Jennifer E., Li, Na, Engelward, Bevin P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827959/
https://ncbi.nlm.nih.gov/pubmed/28370323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22082
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