Age-related cancer mutations associated with clonal hematopoietic expansion

Several genetic alterations characteristic of leukemia and lymphoma have been detected in the blood of individuals without apparent hematological malignancies. We analyzed blood-derived sequence data from 2,728 individuals within The Cancer Genome Atlas, and discovered 77 blood-specific mutations in...

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Publicado no:Nat Med
Main Authors: Xie, Mingchao, Lu, Charles, Wang, Jiayin, McLellan, Michael D., Johnson, Kimberly J., Wendl, Michael C., McMichael, Joshua F., Schmidt, Heather K., Yellapantula, Venkata, Miller, Christopher A., Ozenberger, Bradley A., Welch, John S., Link, Daniel C., Walter, Matthew J., Mardis, Elaine R., Dipersio, John F., Chen, Feng, Wilson, Richard K., Ley, Timothy J., Ding, Li
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313872/
https://ncbi.nlm.nih.gov/pubmed/25326804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3733
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