Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC

Neurosteroids are endogenous sterols that potentiate or inhibit pentameric ligand-gated ion channels (pLGICs) and can be effective anesthetics, analgesics, or anti-epileptic drugs. The complex effects of neurosteroids on pLGICs suggest the presence of multiple binding sites in these receptors. Here,...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Cheng, Wayland W. L., Chen, Zi-Wei, Bracamontes, John R., Budelier, Melissa M., Krishnan, Kathiresan, Shin, Daniel J., Wang, Cunde, Jiang, Xin, Covey, Douglas F., Akk, Gustav, Evers, Alex S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Molecular Biophysics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827446/
https://ncbi.nlm.nih.gov/pubmed/29301936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000359
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