Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct

Acrolein, an α,β-unsaturated aldehyde, is generated in vivo as the end product of lipid peroxidation and from metabolic oxidation of polyamines, and it is a ubiquitous environmental pollutant. The reaction of acrolein with the N2 of guanine in DNA leads to the formation of γ-hydroxy-1-N(2)-propano-2...

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Vydáno v:J Biol Chem
Hlavní autoři: Yoon, Jung-Hoon, Hodge, Richard P., Hackfeld, Linda C., Park, Jeseong, Roy Choudhury, Jayati, Prakash, Satya, Prakash, Louise
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827445/
https://ncbi.nlm.nih.gov/pubmed/29330301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000962
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