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Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct
Acrolein, an α,β-unsaturated aldehyde, is generated in vivo as the end product of lipid peroxidation and from metabolic oxidation of polyamines, and it is a ubiquitous environmental pollutant. The reaction of acrolein with the N2 of guanine in DNA leads to the formation of γ-hydroxy-1-N(2)-propano-2...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5827445/ https://ncbi.nlm.nih.gov/pubmed/29330301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000962 |
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