The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling

Retinoic acid-inducible gene I (RIG-I) is a key pattern recognition receptor that senses viral RNA and interacts with the mitochondrial adaptor MAVS, triggering a signaling cascade that results in the production of type I interferons (IFNs). This signaling axis is initiated by K63-linked ubiquitinat...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Chiang, Cindy, Pauli, Eva-Katharina, Biryukov, Jennifer, Feister, Katharina F., Meng, Melissa, White, Elizabeth A., Münger, Karl, Howley, Peter M., Meyers, Craig, Gack, Michaela U.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827370/
https://ncbi.nlm.nih.gov/pubmed/29263274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01737-17
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