THE PHYSICAL SPACING BETWEEN THE VON WILLEBRAND FACTOR D’D3- AND A1- DOMAINS REGULATES PLATELET ADHESION IN VITRO AND IN VIVO

BACKGROUND: Previous ex vivo studies using truncated VWF (Von Willebrand Factor) suggest that domain-level molecular architecture may control platelet-GpIbα binding function. OBJECTIVE: We determined if this is the case with multimeric VWF in vivo. METHODS: Full-length human VWF (‘hV’) was modified...

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Detalhes bibliográficos
Publicado no:J Thromb Haemost
Main Authors: Zhang, Changjie, Kelkar, Anju, Nasirikenari, Mehrab, Lau, Joseph T.Y., Sveinsson, Michele, Sharma, Umesh C., Pokharel, Saraswati, Neelamegham, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826847/
https://ncbi.nlm.nih.gov/pubmed/29251812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13927
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