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Activation of the anti-aging and cognition-enhancing gene Klotho by CRISPR-dCas9 transcriptional effector complex

Multiple lines of evidence show that the anti-aging and cognition-enhancing protein Klotho fosters neuronal survival, increases the anti-oxidative stress defense and promotes remyelination of demyelinated axons. Thus, upregulation of the Klotho gene can potentially alleviate the symptoms and/or prev...

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Détails bibliographiques
Publié dans:J Mol Neurosci
Auteurs principaux: Chen, Ci-Di, Zeldich, Ella, Li, Yuexuan, Yuste, Andrea, Abraham, Carmela R.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826803/
https://ncbi.nlm.nih.gov/pubmed/29352444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-017-1011-0
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